バイオメディカルリサーチ講座
BIOMEDICAL RESEARCH LABORATORY
岐阜薬科大学
2025年 研究論文
欧文 3報
2025年4月1日
34. Pentadecyl, an active component of microalgae, ameliorates endoplasmic reticulum stress and blue light-induced cell death in mouse retina-derived 661W cells
Obayashi M., Otsu W., Yamazaki K., Nakamura S., Ishikawa H., Sakata Y., Tsuboi M., Tsusaki H., Shimazawa M.
Biol. Pharm. Bull., in press
2025年3月28日
33. Oral administration of heat-killed Fructobacillus fructosus FMO-85 alleviates the reduction in tear fluid in a stress-induced dry eye mouse model
Sugisawa E., Otsu W., Yako T., Hata T., Morimoto T., Maruyama H., Kono H., Nakamura S., Tsusaki H., Shimazawa M.
BPB Reports, in press
2023年11月13日
32. Macular white dot lesions with hyperreflective optical coherence tomography findings in cynomolgus and rhesus monkeys
Araki T., Shimazawa M., Nakamura S., Otsu W., Numata Y., Sakata M., Kabayama K., Tsusaki H., and Hara H.
Mol. Vis., in press
2024年 研究論文
欧文 5報
2024年10月28日
31. NAMPT activator P7C3-A20 protects against tunicamycin-induced cell injury in C2C12 murine myoblast cells
Chinen N., Otsu W., Kuse Y., Nakamura S., Hara H., Shimazawa M.
BPB Reports, 7(6), 212-217, 2024.
2024年10月2日
30. Intranasal administration of liposomes can deliver drugs to the posterior ophthalmic region in addition to the brain
Tsuji S., Hatano R., Nakamura S., Kudo U., Aoshima K., Fujimori H., Takagi Y., Obayashi M., Ito T., Yamazoe E., KuseY., Otsu W., Shimazawa M., Tahara K.
J. Drug Deliv. Sci. Technol.,101, 106254, 2024.
2024年6月28日
29. Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated retinal degeneration
Fu C., Yang N., Chuang JZ., Nakajima N., Iraha S., Roy N., Wu Z., Jiang Z., Otsu W., Radu RA., Yang HH., Lee MP., Worgall TS., Xiong WC, and Sung CH.
Nat. Commun.,15(1):5970, 2024.
2024年2月1日
28. Investigation into the usefulness of cynomolgus monkeys with spontaneously elevated intraocular pressure as a model for glaucoma treatment research
Araki T., Shimazawa M., Nakamura S., Otsu W., Numata Y., Sakata M., Kabayama K., Tsusaki H., and Hara H.
J. Pharmacol. Sci., 154(2), 52-60, 2024
2024年1月2日
27. Delphinidins from Maqui berry (Aristotelia chilensis) ameliorate the subcellular organelle damage induced by blue light exposure in murine photoreceptor-derived cells
Yamazaki K., Ishida K., Otsu W., Muramatsu A., Nakamura S., Yamada W., Tsusaki H., Shimoda H., Hara H., and Shimazawa M.
BMC Complement. Med.Ther., 24(3), 2024
2023年 研究論文
欧文 3報
2023年5月31日
26. Protective effect of crocetin against cytoskeletal injury induced by acrolein from cigarette smoke extract in C2C12 myoblasts
Otsu W., Chinen N., Sugisawa E., Kitano H., Nakamura S., Umigai N., Tsusaki H., and Shimazawa M.
J. Funct. Foods, 106, 105611, 2023.
2023年5月25日
25. Protective effect of Vaccinium myrtillus L. extract against UVA-induced injury in ARPE-19 cells
Otsu W., Hara H., and Ogawa K.
Food Sci. Technol. Res., 29(5), 403-411, 2023
2023年4月20日
24. Blueberry stem extract suppresses blue light emitting diode light induced endoplasmic reticulum stress on retinal photoreceptor cells
Ogawa K., Karitani T, Otsu W., Nishiyama K., Kunitake H., Goto Y., Nomiyama S., Hara H., and Yamasaki M.
BPB Reports, 6(3), 87-97, 2023.
2022年 研究論文
欧文 4報
2022年10月14日
23. Crocetin protects against mitochondrial damage induced by UV-A irradiation in corneal epithelial cell line HCE-T cells
Otsu W., Yako T., Sugisawa E., Nakamura S., Tsusaki H., Umigai N., Shimazawa M., and Hara H.
J. Pharmacol. Sci.,150(4):279-288, 2022.
2022年4月29日
22. The pathological association between the anterior eye segment and the retina in a murine model of neovascular glaucoma
Nishinaka A., Tanaka M., Aoshima K., Kuriyama A., Sasaki T., Otsu W., Yasuda H., Nakamura S., Shimazawa M., and Hara H.
FASEB J., 36(6):e22323, 2022.
2022年2月4日
21. Lipid droplet accumulation promotes RPE dysfunction
Yako T., Otsu W., Nakamura S., Shimazawa M., and Hara H.
Int. J. Mol. Sci., 23(3): 1790, 2022.
2022年1月18日
20. Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration
*Chuang JZ., *Yang N., *Nakajima N., *Otsu W., Fu C., Yang HH., Lee MP., Akbar AF., Bdea TC., Guo Z., Nuruzzaman A., Hsu KS., Dunaief JL., and Sung CH.
Nat. Commun., 13(1):375, 2022.
*Contributed equally
2021年 研究論文
欧文 6報
2021年10月20日
19. Mitochondria dynamics in the aged mice eye and the role in the RPE phagocytosis
Yako T., Nakamura M., Otsu W., Nakamura S., Shimazawa M., and Hara H.
Exp. Eye Res., 213, 108800, 2021.
2021年9月17日
18. Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells
*Otsu W., *Ishida K., Chinen N., Nakamura S., Shimazawa M., Tsusaki H.,and Hara H.
Sci. Rep., 11(1):18555, 2021.
*Contributed equally
2021年7月25日
17. Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation
Takahashi K., Nakamura S., Otsu W., Shimazawa M., and Hara H.
J. Neuroinflamm., 18(1), 164, 2021.
2021年7月1日
16. Free-radical scavenger NSP-116 protects the corneal epithelium against UV-A and blue LED light exposure
Ishida K., Yako T., Tanaka M., Otsu W., Nakamura S., Shimazawa M., Tsusaki H., and Hara H.
Biol. Pharm. Bull., 44(7):937-946, 2021.
2021年1月6日
15. Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion
Miyagi S., Nishinaka A., Yamamoto T., Otsu W., Nakamura S., Shimazawa M., Kataoka T., and Hara H.
Exp. Eye Res., 204, 108441, 2021.
2020年8月31日
14. Creation of retinal vein occlusion model in cynomolgus monkeys and determination of its pathological features
Inagaki S., Shimazawa M., Otsu W., Araki T., Numata Y., Nakamura S., Tsusaki H., and Hara H.
Curr. Neurovasc. Res., 18(1): 123-133, 2021.
2020年 研究論文
欧文 8報
2020年12月2日
13. Brazilian green propolis promotes the cytoprotective expression of heme oxygenase-1 against oxidative stress injury in murine myoblast cells
Chinen N., Otsu W., Ohuchi K., Ando S., Nakamura S., Kono H., Shimazawa M., and Hara H.
Functional Foods in Health and Disease, 10(12); 493-504, 2020.
2020年7月30日
12. Survival motor neuron protein modulates lysosomal function through the expression of transcription factor EB in motoneurons
Ando S., Otsu W., Osanai D., Kamiya S., Ishida K., Nakamura S., Shimazawa M., and Hara H.
BPB Reports, 3(4); 130-137, 2020.
2020年7月11日
11. Central nervous system migration of astaxanthin and adonixanthin following their oral administration in cynomolgus monkeys
Nakamura S., Maoka T., Tsuji S., Hayashi M., Shimazawa M., and Hara H.
J. Nutr. Sci. Vitaminol., 66(5): 488-494, 2020.
2020年6月5日
10. Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts
Kiatpakdee B., Sato K., Otsuka Y., Arashiki N., Chen Y., Tsumita T., Otsu W., Yamamoto A., Kawata R., Yamazaki J., Sugimoto Y., Takada K., Mohandas N., and Inaba M.
J. Biol. Chem., 295(23); 8048-8063, 2020.
2020年5月26日
9. Tauroursodeoxycholic acid promotes neuronal survival and proliferation of tissue resident stem and progenitor cells in retina of adult zebrafish
Saito Y., Okuyoshi H., Nakamura S., Otsu W., Yamaguchi A., Hitchcock P.F., Nagashima M, Shimazawa M., and Hara H.
BPB Reports, 3(3); 92-96, 2020.
2020年5月23日
8. Anti-vascular endothelial growth factor antibody limits vascular leakage and decreases subretinal fibrosis in a cynomolgus monkey choroidal neovascularization model
Inagaki S., Shimazawa M., Hamaguchi K., Otsu W., Araki T., Sasaki Y., Numata Y., Tsusaki H., and Hara H.
Curr. Neurovasc. Res., 17(4); 420-428, 2020.
2020年3月28日
7. Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells
Otsu W., Ishida K., Nakamura S., Shimazawa M., Tsusaki H.,and Hara H.
Biochem. Biophys. Res. Commun., 526(2); 479-484, 2020.
2020年5月20日
6. A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner
Saito Y., Yako T., Otsu W., Nakamura S., Inoue Y., Muramatsu A., Nakagami Y., Shimazawa M., and Hara H.
Free Radic. Biol. Med., 152; 235-247, 2020.
2019年 研究論文
欧文 3報
5. CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells
*Hsu KS, *Otsu W., Li Y., Wang HC., Chen S., Tsang SH., Chuang JZ., and Sung CH.
Sci. Rep., 9(1); 12247, 2019.
*Contributed equally.
4. The Late Endosomal Pathway Regulates the Ciliary Targeting of Tetraspanin Protein Peripherin 2
Otsu W., Hsu YC., Chuang JZ., and Sung CH.
J. Neurosci., 39(18); 3376-3393, 2019.
3. Nrf2 activator RS9 suppresses pathological ocular angiogenesis and hyperpermeability
Nakamura S., Noguchi T., Inoue Y., Sakurai S., Nishinaka A., Hida Y., Masuda T., Nakagami Y., Horai N., Tsusaki H., Hara H., and Shimazawa M.
Invest. Ophthalmol. Vis. Sci., 60(6); 1943-1952, 2019.
2018年 研究論文
欧文 ２報
2. Relationship between elevated intraocular pressure and divided peripapillary sector retinal nerve fiber layer thickness in a cynomolgus monkey laser-induced ocular hypertension model
Noguchi T., Shimazawa M., Hamaguchi K., Araki T., Horai N., and Hara H.
Ophthalmic Res., 58; 99-106, 2017.
1. Movement of retinal vessels toward the optic nerve head after increasing intraocular pressure in monkey eyes with experimental glaucoma
Kuroda A., Enomoto N., Ishida K., Shimazawa M., Noguchi T., Horai N., Onoe H., Hara H. and Tomita G.
Exp. Eye Res., 162; 110-115, 2017.